您的位置：网站首页 > 《中文科技期刊数据库》 > 医药卫生 > 临床医学 > 摘要
Nitric oxide： orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response
WeimingXU IanG.CHARLES SalvadorMONCADA WolfsonInstituteforBiomedicalResearch UniversityCollegeLondon TheCruciformBuilding GowerStreet London WC1E6BT UK
|
摘要：Mitochondria have long been considered to be the powerhouse of the living cell, generating energy in the form of the molecule ATP via the process of oxidative phosphorylation. In the past 20 years, it has been recognised that they also play an important role in the implementation of apoptosis, or programmed cell death. More recently it has become evident that mitochondria also participate in the orchestration of cellular defence responses. At physiological concentrations, the gaseous molecule nitric oxide (NO) inhibits the mitochondrial enzyme cytochrome c oxidase (complex Ⅳ) in competition with oxygen. This interaction underlies the mitochondrial actions of NO, which range from the physiological regulation of cell respiration, through mitochondrial signalling, to the development of “metabolic hypoxia”-a situation in which, although oxygen is available, the cell is unable to utilise it. | |
|---|---|---|
| 格式：PDF 页数：3 页 页码范围：63-65页 | ||
学科分类：
|
||
| 关 键 词：一氧化氮 缺氧症 线粒体 内质网 呼吸作用 氧化磷酸化 细胞凋亡 细胞信号转导 | ||
| 来源期刊：《细胞研究：英文版》2005年 第1期 | ||
| 收录数据库：中文科技期刊数据库 | ||
|
||
